• The Center
  • Board of Directors
  • Steering Committee and Administrative Staff
  • Departmental Affiliations
  • Research Personnel
  • Index of Faculty Members
• Education
  • Biomedical Training
  • Lecture Series
  • Continuing Medical Education
  • Community and Professional Outreach
• Research
  • Basic Research
  • Clinical Research
  • Collaborations
  • Educational Research
  • Grant Opportunities
  • Grants Awarded
  • Recent Publications
  • Topics of Research
• Clinical Application
  • Clinical Trials
  • Translational Research
  • Collaborating Healthcare Professionals
• Links
  • Other Sites
  • SeekHealth Sites

CCDA
4170 City Ave.
Philadelphia, PA 19131

ccda@pcom.edu
t. 215-871-6961
f. 215-871-6869

Brian J. Balin, PhD - Publications

Peer-Reviewed Publications

Appelt, D.M., Roupas, M., Hammond, C.J., Little, C.S., and Balin, B.J.: Apoptotic effects of Chlamydophila pneumoniae following infection of neuronal cells. (Submitted BMC Neuroscience), 2007.

Way, D., Albert, E., Hammond, C., Bell, M., Balin, B., Appelt, D. Caspase activity is inhibited in neuronal cells infected with Chlamydia pneumoniae: implications for apoptosis in Alzheimer's disease. In Alzheimer's disease: New Advances, Medimond Internatl Proceedings, 295-99, 2006.

Hammond, C., Little, C.S., Longo, N., Procacci, C., Appelt, D., Balin, B. Antibiotic alters inflammation in the mouse brain during persistent Chlamydia pneumoniae infection. In Alzheimer's disease: New Advances, Medimond Internatl Proceedings, 537-540, 2006.

Balin, B., Hammond, C., Taylor, A., Tuitt, K., Abraham, J., Appelt, D. Immunodetection of Chlamydophila (Chlamydia) pneumoniae in the Alzheimer brain. In Alzheimer's disease: New Advances, Medimond Internatl Proceedings, 301-5, 2006.

Narins, S.C., Park, E.H., Ramakrishnan, R., Garcia, F.U., Diven, J.N., Balin, B.J., Hammond, C.J., Sodam, B.R., Smith, P.R., Abedin, M.Z. Functional characterization of Na(+)/(H+) exchangers in primary cultures of prairie dog gallbladder. J. Membr. Biol. 197:123-134, 2004.

Abrams, J.T., Balin, B.J., and Vonderheid, E.C.: Association between Sezary T Cell Activating Factor, Chlamydia pneumoniae, and Cutaneous T Cell Lymphoma. New York Acad Sci 941:69-85, 2001.

Katsetos, C.D., Valle, L.D., Geddes, J.F., Assimakopoulou, M., Legido, A., Boyd, J.C., Balin, B., Parikh, N.A., Maraziotis, T., de Chadarevian, J-P., Varakis, J.N., Matsas, R., Frankfurter, A., Herman, M.M., and Khalili, K.: Aberrant localization of the neuronal class III beta-tubulin in astrocytomas. Arch Pathol Lab Med 125(5):613-624, 2001.

Abrams, J.T., Vonderheid, E.C., Kolby, S.J., Appelt, D.M., Arking, E.J., and Balin, B.J.: Sezary T Cell Activating Factor is a Chlamydia pneumoniae associated protein. Clin. Diag. Lab. Immuno. 6 (6):895-905, 1999.

Gerard H.C., Wang G.F., Balin, B.J., Schumacher H.R., and Hudson A.P.: Frequency of apolipoprotein E (APOE) allele types in patients with Chlamydia-associated arthritis and other arthritides. Microbial Pathogenesis 26:35-43, 1999.

Reed, L.A., Schmidt, M.L., Wszolek, Z.K., Balin, B.J., Sootorniyomkij, V., Lee, V.M.-Y., Trojanowski, J.Q., and Schelper, R.L.: The Neuropathology of Chromosome 17-linked Autosomal Dominant Parkinsonism-Dementia (Pallido-ponto-nigral degeneration). J. Neuropath. & Exper. Neurol. 57:588-601, 1998.

Lieberman, A.P., Trojanowski, J.Q., Lee, V.M.-Y., Balin, B.J., Ding, X.-S., and Grossman, M.: Cognitive, Neuroimaging, and Pathological studies of Pick's Disease. Ann. Neurol 43:259-265, 1998.

Katsetos, C.D., Herman, M.M., Balin, B.J., Arking, E.J., Vinores, S.A., Karkavelas, G. and Frankfurter, A.: Divergent neuronal and glial differentiation of the PC12 rat pheo-chromocytoma cell line maintained in a gelfoam matrix system: An immunoperoxidase and immunoblot study with antibodies to neuronal cytoskeletal proteins, synaptophysin, GFAP and S100 protein. Anat. Record 250:351-365, 1998.

Appelt, D.M. and Balin, B.J.: The association of tissue transglutaminase with human recombinant tau results in the formation of insoluble filamentous structures. Brain Res. 745:21-31, 1997.

Mawal-Dewan, M., Schmidt, M.L., Balin, B.J., Perl D.P., Lee, M.-Y.L. and Trojanowski, J.Q.: Identification of phosphorylated sites in PHF-tau from patients with Guam Amyotrophic lateral sclerosis/Parkinsonism-Dementia Complex. J. Neuropathol. Exper. Neurol. 55:1051-1059, 1996.

Appelt, D.M., Kopen, G.C., Boyne, L.J. and Balin, B.J.: Localization of transglutaminase in hippocampal neurons: Implications for Alzheimer Disease. J. Histochem. Cytochem. 44: 1421-1427, 1996.

Balin, B.J. and Miller, M. E.: Assembly of the 66kDa neurofilament protein in vitro and its association with NF-L, NF-M and NF-H purified from bovine spinal cord. J. Neurosci. Res. 40: 79-88, 1995.

Appelt, D.M. and Balin, B.J.: Analysis of paired helical filaments found in Alzheimer's Disease using freeze-drying/rotary shadowing. J. Struct. Biol. 111: 85-95,1993.

Mulligan, L., Balin, B.J., Lee, V.M.-Y., Ip, W.: Antibody labeling of bovine neurofilaments: Implications on the structure of neurofilament sidearms. J. Struct. Biol. 106:145-160, 1991.

Balin, B.J. and Lee, V.M.-Y.: Individual neurofilament subunits reassembled in vitro exhibit unique biochemical, morphological and immunological properties. Brain Res. 556: 196-208, 1991.

Balin, B.J., Clark, E.A., Trojanowski, J.Q. and Lee, V.M-Y.: Neurofilament reassembly In Vitro: Biochemical, Morphological and Immunoelectron microscopic studies employing monoclonal antibodies to defined epitopes. Brain Res. 556: 181-195, 1991.

Lee, V.M.-Y., Balin, B.J., Otvos Jr., L., Hollosi, M. and Trojanowski, J.Q.: A68: A major subunit of paired helical filaments and derivatized forms of normal Tau. Science 251: 675-678, 1991.

Broadwell, R.D., Balin, B.J., Salcman, M.: Transcytotic pathway for blood-borne protein through the blood-brain barrier. Proc. Natl. Acad. Sci. USA 85: 632-636, 1988.

Balin, B.J. and Broadwell, R.D.: Transcytosis of protein through the mammalian cerebral epithelium and endothelium. I. Choroid plexus and the blood-cerebrospinal fluid barrier. J. Neurocytol. 17: 1-18, 1988.

Broadwell, R.D., Charlton, H.M., Balin, B.J. and Salcman, M: Angioarchitecture of the CNS, Pituitary Gland, and Intracerebral Grafts Revealed with Peroxidase Cytochemistry. J. Comp Neurol. 260: 47-62, 1987.

Broadwell, R.D., Balin, B.J. and Salcman, M.: Polarity of the blood-brain barrier to the endocytosis of exogenous protein. Wiss. K.Marx-U. Math.-Naturwis. 36:171-175, 1987.

Balin, B.J., Broadwell, R.D. and Salcman,M.: Tubular profiles do not form transendo-thelial channels through the blood-brain barrier. J. Neurocytol. 16: 721-735, 1987.

Balin, B.J. and Broadwell, R.D.: Lectin-labeled membrane is transferred to the Golgi Complex in mouse pituitary cells in vivo. J. Histochem. Cytochem. 35: 489-498, 1987.

Balin, B.J., Broadwell, R.D., Salcman, M. and El-Kalliny, M.: Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat and squirrel monkey. J. Comp. Neurol. 251(2): 260-280, 1986.

Broadwell, R.D. and Balin, B.J.: Endocytic and exocytic pathways of the neuronal secretory process and trans-synaptic transfer of wheat germ agglutinin-horseradish peroxidase in vivo. J. Comp. Neurol. 242: 632-650, 1985.

Broadwell, R.D., Cataldo, A.M. and Balin, B.J.: Further studies of the secretory process in hypothalamo neurohypophysial neurons. An analysis using immunochemistry, wheat germ agglutinin-peroxidase and native peroxidase. J. Comp. Neurol. 228:155-167, 1984.

Broadwell, R.D., Balin, B.J., Salcman, M. and Kaplan, R.S.: A brain-blood barrier? Yes and no. Proc. Natl. Acad. Sci. USA 80: 7352-7356, 1983.

Publications: Chapters and Reviews

Broadwell, R.D., Balin, B.J. and Cataldo, A.M.: Fine structure and cytochemistry of the median eminence. In: Gross, P.M., (ed.): Circumventricular Organs and Body Fluids. Boca Raton, Fla.: CRC Press, 1987.

Balin, B.J., Loewy, A.R. and Appelt, D.M.: Analysis of Transglutaminase-catalyzed Isopeptide Bonds in Paired Helical Filaments and Neurofibrillary Tangles From Alzheimer's Disease. In: Amyloid and other protein deposition: methods and models. (Methods in Enzymology 309:172-186, 1999; Academic Press, Orlando, Fl; edited by Ronald Wetzel, Ph.D.).

Balin, B.J. and Binstock, R.H.: Perspectives on Changes in the Human Brain as a Function of Aging. The Gerontologist 39: 745-749, 1999; Comparative book review.

Balin, B.J. and Appelt, D.M.: Transglutaminase-catalyzed Formation of Alzheimer-like Insoluble Complexes From Recombinant Tau. In:Alzheimer's Disease: Methods and Protocols. (In Methods in Molecular Medicine, pp 395-403, The Humana Press, Inc., Totowa, NJ; edited by Dr. Nigel M. Hooper, 2000).

Hudson, A.P., Gerard, H.C., Whittum-Hudson, J.A., Appelt, D.M., Balin, B.J.: Chlamydia pneumoniae, APOE genotype, and Alzheimer's Disease. In: Chlamydia pneumoniae and Chronic Diseases, pp 121-136, 2000; Springer-Verlag, Berlin, Germany; edited by Johanna L'Age-Stehr).

Balin, B.J., Appelt, D.M.: The Role of Infection in Alzheimer's Disease. Journal of the American Osteopathic Association 101 (12 Suppl PT 1): S1-S6, 2001.

Balin, B.J., Appelt, D.M., Whittum-Hudson, J.A., Hudson, A.P.: Infectious Agents and Alzheimer's Disease. Recent Research Developments in Molecular and Cellular Biochemistry 1:187-202, 2003.

Balin, B.J., Hammond, C.J., Little, C.S, MacIntyre, A., Appelt, D.M.: Chlamydia pneumoniae in the Pathogenesis of Alzheimer's disease. In: Chlamydia Pneumoniae Infection and Diseases. Kluwer Academic/Plenum Publishers, New York, New York; Edited by Drs. M. Bendinelli, Y. Yamamoto, and H. Friedman, 2004, pp. 211-226.

Young, L.H., Balin, B.J., and Weis, M.T.: Go 6983: A fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovascular Drug Reviews 23: 255-272, 2005.

Balin, B.J., Appelt, D.M., Little, C.S., Hammond, C.J., Whittum-Hudson, J.A., Hudson, A.P.: Chlamydophila (Chlamydia) pneumoniae in Alzheimer's disease. In: Microbial Infections of the Neurologic System. Springer Publishers; Edited by Andreas Seyfang, H. Friedman, and M. Bendinelli, (in press), 2007.

« back