Qian Chen, PhD
Dr. Qian Chen is a Research Assistant Professor in the Department of Pathology, Microbiology, Immunology and Forensic Medicine after two and half years of postdoctoral training at PCOM. Dr. Chen currently collaborates with Dr. Young and has made substantial contributions in sequestering NIH grant funding, authoring peer-reviewed publications/poster presentations and training graduate/DO students. She received her PhD in Cardiology from the Xi'an Jiao Tong University College of Medicine in 2001 in China. Dr. Chen is a member of Neuroscience Society and Sigma Xi Scientific Research Society.
Dr Chen's research interest is to understand the pathological changes in vascular endothelial dysfunction under various disease conditions, such as myocardial infarction, stroke and diabetes. Because vascular endothelial dysfunction is one of earliest events occurring in many diseases, the clarification of the related mechanisms can provide a new strategy for treatment. Protein kinase C is very important for regulating vascular endothelial function. However, the function and changes of different PKC isoforms in different diseases are still unclear. Currently, she is conducting experiments to understand the role of different PKC isoforms in regulating leukocyte-endothelium interactions in vivo by using intravital microscopy. She is also planning to combine intravital microscopy with measurement of free radicals to relate the oxidative stress in leukocyte-endothelial interactions under pathological conditions, such as hyperglycemia.
CCDA Pilot Research Project: 2008
PKC isoform inhibition in leukocyte-endothelial interactions by using intravital microscopy
Jane Teng, Helen Kay, Qian Chen, Jovan Adams, Christopher Zambrano, Samuel Krass, Christopher Grilli, Giuseppe Guglielmello, Adrian Bell and Lindon Young. Mechanisms related to the cardioprotective effects of protein Kinase C epsilon peptide activator (PKC s+) or inhibitor (PKC s-) in rat ischemia/reperfusion injury. Naunyn-Schmiedeberg's Archives of Pharmacology 378(1) 1-15, 2008.
Mickael Derangeon, Nicolas Bourmeyster, Isabelle Plaisance, Qian Chen, Fabien Duthe, Michel R. Popoff, Denis Sarrouilhe, and Jean-Claude Herve. RhoA GTPase and F-actin dynamically regulate the permeability of Cx43-made channels in rat cardiac myocytes. J Bio Chem. 283(45):30754-65, 2008.
Qian Chen, Hui-Lin Pan. Signaling mechanisms of angiotensin II-induced attenuation of GABAergic input to hypothalamic presympathetic neurons. Neurophysiology, 97(5):3279-87, 2007.
Qian Chen, Hui-Lin Pan. Regulation of synaptic input to hypothalamic presympathetic neurons by GABA(B) receptors. Neuroscience 142: 595-606, 2006.
Qian Chen, De-Pei Li, Hui-Lin Pan. Presynaptic A1-adrenergic receptors regulate synaptic inputs to spinally projecting paraventricular neurons. J Pharmacol Exp. Ther. 316(2): 733-42, 2006.
Xin-wen Yu, Qian Chen, Richard H Kennedy, Shi J Liu. Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes. J Physiol. 556(2): 327-340, 2005.