C. Scott Little, PhD
Dr. Scott Little joined the Department of Pathology, Microbiology, Immunology, and Forensic Medicine as an Instructor and Research Associate in 2001 and is currently an Assistant Professor in the department. Prior to joining the Department, he was a Post-Doctoral Fellow in the Biomedical Sciences Department here at PCOM. He received his PhD in Molecular Pathobiology from the Medical College of Philadelphia-Hahnemann University.
Research
Dr. Little's research interests include immunology and chronic infection associated with diseases of aging, specifically the role of the immune system in modulating disease severity. One research focus includes the identification of elements of the immune system critical in the prevention of dissemination of the respiratory pathogen, Chlamydia pneumoniae, to extra-respiratory sites. He has been published for work studying the role of Chlamydia pneumoniae infection in the induction of Alzheimer-like pathology in non-transgenic mice. The experimental induction of Alzheimer-like pathology in non-transgenic mice serves as a model for the sporadic/late onset form of Alzheimer's disease. His research interests also include the study of food allergy, particularly life-threatening allergic reactions upon exposure to peanuts. Dr. Little is a member of The Microscopy Society of America and Sigma Xi Scientific Research Society.
Email: chrisl@pcom.edu
Awards
CCDA Pilot Research Project; 2007
Development and immune modulation of peanut allergy in BALB/c and C3H/HeJ mice
Recent Publications
Chlamydophila pneumoniae and the etiology of late-onset Alzheimer's disease. Balin, B.J., Little, C.S., Hammond, C. J., Appelt, D. M., Whittum-Hudson, J.A., Gerard, H.C., Hudson, A.P., 2007. Journal of Alzheimers Disease (Accepted).
Antibiotic Alters Inflammation in the Mouse Brain During Persistent Chlamydia pneumoniae Infection. Hammond, C., Little, C.S, Longo, N., Procacci, C., Appelt, D.M., Balin, B.J., 2006. 10th ICAD & Related Disorders; Alzheimer's Disease New Advances; 295-299.
Age alterations in extent and severity of experimental intranasal infection by Chlamydophila pneumoniae in BALB/c mice. Little, C. S., A. Bowe, R. Y. D. Lin, J. Litsky, R. M. Fogel, B. J. Balin, and K. L. Fresa-Dillon. 2005. Infection and Immunity 73: 1723-1734.
Chlamydia pneumoniae induces Alzheimer-like amyloid plaques in brains of BALB/c mice. Little, C. S., C. J. Hammond, A. MacIntyre, B. J. Balin, and D. M. Appelt. 2004. Neurobiology of Aging 25:419-429.
Chlamydia pneumoniae in the Pathogenesis of Alzheimer's Disease. Balin, B. J., C.J. Hammond, C. S. Little, A. MacIntyre, and D. M. Appelt. 2003. In: Chlamydia pneumoniae Infection and Diseases, H. Friedman ed., Kluwer Academic Plenum, New York, NY. p211-226.
Chlamydia pneumoniae infection promotes the transmigration of monocytes through human brain endothelial cells. MacIntyre, A., R. Abramov, C. J. Hammond, A. P. Hudson, E. J. Arking, C. S. Little, D. M. Appelt, and B. J. Balin. 2003. J. Neuroscience Research 71:740-750.
Chlamydia pneumoniae infection alters the junctional complex proteins of human brain microvascular endothelial cells. MacIntyre, A., C. J. Hammond, C. S. Little, D. M. Appelt, and B. J. Balin. 2002. FEMS Microbiology Letters 217:167-172.
Ultrastructural analysis of beta-amyloid production in monocytes, epithelial, and endothelial cells infected with Chlamydia pneumoniae isolated from Alzheimer brains. Little, C. S., A. MacIntyre, C. Hammond, E. Venuti, B. J. Bromke, B. J. Balin, and D. M. Appelt. 2000. EXPO:Microscopy and Microanalysis. Vol. 6 (S1):411.
Rational design of cytotoxic T-cell inhibitors. Tretiakova, A. P., C. S. Little, K. J. Blank, and B. A. Jameson. 2000. Nature Biotechnology 18:984-988.
Differences in the immune response during the acute phase of E-55+ murine leukemia virus infection in progressor BALB and long term nonprogressor C57BL mice. Panoutsakopoulou, V., C. S. Little, T. G. Sieck, E. P. Blankenhorn, and K. J. Blank. 1998. The Journal of Immunology 161:17-26.